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What is Hyalgan®?

Hyalgan® is a solution that contains a natural substance called hyaluronate. Hyaluronate is normally found in the fluid that lubricates and cushions your knee joint. Hyalgan® is injected into your knee to relieve pain due to osteoarthritis. Hyalgan® is a treatment option for people who do not get Adequate Pain Relief from simple painkillers (like Tylenol® or Advil®) or from exercise and physical therapy. Hyalgan® injections can be used in addition to prescription pain relievers. Hyalgan® is injected directly into your knee by your health care provider. Hyalgan® is a 5-injection regimen given at weekly intervals that provides long-lasting pain relief for up to 6 months. Some patients get benefits with 3 injections given at weekly intervals.

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Important Safety Information About Hyalgan®

Hyalgan® is contraindicated in patients with known hypersensitivity to hyaluronate preparations or in cases of Present Infections or Skin Diseases in the area of the injection site. Use caution when injecting Hyalgan® into patients who are allergic to avian proteins, feathers, and egg products. The safety and effectiveness of Hyalgan® have not been established in children or in pregnant or lactating women, for use in other joints, or for concomitant use with other injectables. It is unknown whether Hyalgan® is excreted in human milk. The effectiveness of a single treatment cycle of fewer than 3 injections has not been established. Transient increases in inflammation in the injected knee following Hyalgan® injection have been reported in some Patients With Inflammatory Arthritis and should not be injected if objective signs of inflammation are present. Transient pain and/or swelling of the injected joint may occur after intra-articular injection of Hyalgan®. Anaphylactoid and allergic reactions have been reported with the use of this product.

Side Effects of Hyalgan®:

Common side effects include but are not limited to:

• Injection-site Pain
• Gastrointestinal Complaints
• Headache
• Local Ecchymosis (Bruising)
• Rash
• Local Joint Pain And Swelling
• Local Pruritus (Itching)
• Knee Swelling
• Effusion
• Ecchymosis
• Pruritus
• Warmth, Pain, Redness, Stiffness, Bruising, Or Puffiness Where The Medicine Was Injected
• Nausea, Stomach Pain
• Trouble Walking
• Swelling In Your Hands Or Feet
• Back Pain, Joint Pain, Muscle Pain
• Numbness Or Tingly Feeling
• Headache, Dizziness
• Runny Or Stuffy Nose, Sneezing, Sore Throat
• Fever Or Chills
• Headache
• Muscle Pain Or Cramps
• Severe Pain; Warmth Or Swelling Of One Or More Joints

This is not a complete list of side effects and others may occur.

Cautions To Take Hyalgan®:

You should not receive an Hyalgan® if you have an Infection In Your Knee Or In The Skin around your knee.
You should not receive Hyalgan® if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.
Hyalgan® is not approved for use by anyone younger than 21 years old.
Tell your doctor if you have ever had:

• Blood Clots Or Circulation Problems In Your Legs
• An Allergy To Birds, Feathers, Or Egg Products.

It is not known whether Hyalgan® will harm an unborn baby. Tell your doctor if you are pregnant. It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.